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But if you have inherited a mutation (defect) in one of these genes from either parent, this cancer-preventing protein is less effective, and your chances of developing breast and/or ovarian cancer increase. The lifetime ovarian cancer risk for women with a BRCA1 mutation is estimated to be between 35% and 70%.
Mutations in BRCA1 and BRCA2 are about 10 times more common in those who are Ashkenazi Jewish than those in the general U. This means that if 100 women had a BRCA1 mutation, between 35 and 70 of them would get ovarian cancer.
Researchers have discovered several specific factors that change a woman's likelihood of developing epithelial ovarian cancer.About 5 to 10% of ovarian cancers are a part of family cancer syndromes resulting from inherited changes (mutations) in certain genes.This syndrome is caused by inherited mutations in the genes BRCA1 and BRCA2, as well as possibly some other genes that have not yet been identified.Overall, it seems that obese women (those with a body mass index of at least 30) have a higher risk of developing ovarian cancer.Women who have been pregnant and carried it to term before age 26 have a lower risk of ovarian cancer than women who have not. Women who have their first full-term pregnancy after age 35 or who never carried a pregnancy to term have a higher risk of ovarian cancer. Women who have used oral contraceptives (also known as birth control pills or the pill) have a lower risk of ovarian cancer.